welcome to the rangachari lab
to understanding proteins from the interface of chemistry, biology, and physics
CORE INTEREST AREAS
Protein misfolding and amyloid formation in neurodegenerative diseases
Liquid-liquid phase separation and membraneless organelles in biology
Design and characterization of soft matter and biomaterials
My lab is involved in experimental biophysics and biochemistry of proteins, specifically ‘intrinsically disordered proteins’ that undergo amyloid aggregation toward insoluble inclusions implicated in neurodegenerative diseases, or Liquid-Liquid Phase Separation (LLPS) to form biomolecular condensates that are increasingly observed in cells. We particularly want to understand the conversion between liquid droplets and amyloid aggregates and its role in pathologies. My lab uses various techniques to answer these questions including biophysics, molecular spectroscopy, microscopy, molecular biology, cell culture, and others.
I encourage graduate students who are interested in becoming a part of this journey and to be trained in protein biophysics to contact me for potential positions.